There have been a few threads relating to carburation recently and perhaps this explanation on potential issues relating to use of a 'big' cam and how it can significantly effect carb tuning. The method of drilling the 'butterflys' is soemthing we use to do 40 or 50 years ago. Higher spec' Holley and generic equivalent will now have the adjustabilty needed to do this without drilling the carb.
Running a big camshaft on the street can pose some serious drivability issues with a carburetor. Here, Jeff Smith walks you through how to alleviate that.